Fundamentals of Biophysics – It is generally accepted that in the twenty-fi rst century biology will occupy one of the leading places in science. Biology will make an important contribution not only to our fundamental knowledge but also to the development of medicine, ecology, generation of new living species. Many problems in biology which are of interdisciplinary com- plex character lie at the boundaries between diff erent sciences. To solve such problems it is necessary to apply ideas and methods of other exact sciences and fi rst of all physics, mathematics, chemistry, and physical chemistry. It is by close cooperation between biology and other exact sciences that the development of biophysics as an independent bound- ary science has become possible.
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In this book – Fundamentals of Biophysics the main ideas of modern biophysics are presented in the form accessible to wide circles of readers. Biophysics (biological physics)is a science about physical and physico-chemical mechanisms of interac-
tions which lie in the basis of biological processes. Physical properties of biopolymers and kinetics of cell metabolic reactions are responsible for molecular characteristics of biological processes.
A biomacromolecule as the main structure element in a cell is considered in biophysics as a peculiar molecular machine where energy is transformed and conversed from one type of energy into another. It is pertinent to recall what Bruce Alberts, a well known American biologist, said about a cell. He wrote that“the entire cell can be viewed as a factory that contains an elaborate net- work of interlocking assembly lines, each of which is composed of a set of large protein machines” (Cell, 1998, vol. 92, pp. 291-294). The real understanding of how these protein machines operate demands the knowledge of not only atomic equilibrium structure but also our understanding of kinetic and energy characteristics of inter- mediate transformations. Fundamentals of Biophysics
In the post-genome sequencing era the first priority is given to the mechanisms of intramolecular mobility of mac- romolecular complexes as the base of their activity. Such an approach corresponds to the biophysical concept of directed electron-conforma- tional interactions when energy transformation and reaction product generation become a result of internal interaction between separate parts within the whole macromolecular complex. Fundamentals of Biophysics
In other words, this is the concept of a “physical machine” put forward in 1970-1980s by D.S.Chernavsky, L.A.Blumenfeld, and M.V.Volkelshtein. In theoretical biophysics, generalized kinetic and physical models of interactions allow to describe diff erent biological phenomena. However the analysis of such models clearly demonstrates that diff erent biologi- cal processes can very oft en be similar with respect to their molecu- lar mechanisms. For example, mechanisms of primary photobiological processes photosynthesis, visual reception), enzyme catalysis in the enzyme active center, and ion transfer through membrane channels
are governed by similar physical principles. Fundamentals of Biophysics
It follows that educational programs on biology at universities should necessarily include ideas of physics, mathematics and physical chemistry, thus illustrating their effi ciency in solving biological problems. Biophysics bears the main responsibility to show an important role of regular application of ideas from exact sciences in studying biological processes. Fundamentals of Biophysics
The great experience gained at Moscow State University has shown that this requirement is satisfi ed when teaching of biophysics is carried on within a logically combined independent general course on biophys- ics. Such a lecture course on biophysics is given both to biology and physics undergraduates as well as to bachelors of medicine and agricul- ture. It is useful for scientists working in other fi elds who want to study biological problems using methods of exact sciences. Fundamentals of Biophysics
In this book Fundamentals of Biophysics the main ideas and concepts of theoretical biophysics (kinetics and thermodynamics of biological processes, molecular bio- physics) are presented in a concise and simple form. It makes the base for the biophysical analysis of some important processes (membrane processes, primary photobiological processes and enzyme reactions) analyzed in
Fundamentals of Biophysics . Th e material is quite understandable and acces- sible to specialists of diff erent profi les and background. It is useful for
the subsequent profound studying of biophysics using special literature sources for the application of the biophysical approach in diff erent fi elds of biology.
Free PDF Books: Fundamentals of Biophysics – 2014