Lanzkowsky’s Manual of Pediatric Hematology and Oncology represents the synthesis of personal experience of three decades of active clinical and research endeavors in pediatric hematology and oncology. The basic orientation and intent of the book is clinical, and the book reflects a uniform systematic approach to the diagnosis and man- agement of hematologic and oncologic diseases in children. The book is designed to cover the entire spectrum of these diseases, and although emphasis is placed on relatively common disorders, rare disorders are included for the sake of completion. Recent developments in hematology-oncology based on pertinent advances in molecular genetics, cytogenetics, immunology, transplantation, and biochemistry are included if the issues have proven of value and applicability to clinical practice.
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Our aim in writing this manual was to cull pertinent and useful clinical information from the recent literature in pediatric hematology and oncology and to temper it with experience derived from active clinical practice. The result, we hope, is a concise, practical, readable, up-to-date book for practitioners responsible for the care of children with hematologic and oncologic diseases.
It is specifically designed for the medical student and practitioner seeking more detailed information on the subject, the pediatric house officer responsible for the care of patients with these disorders, the fellow in pediatric hematology-oncology seeking a systemic approach to these diseases and a guide in preparation for the board examinations, and the practicing pediatric hematologist-oncologist seeking another opinion and approach to these disorders. As with all brief texts, some dogmatism and “matters of opinion” have been unavoidable in the interests of clarity. The opinions expressed on management are prudent clinical opinions; and although they may not be accepted by all, pediatric hematologists-oncologists will certainly find a consensus.
The reader is presented with a consistency of approach and philosophy describing the management of various diseases rather than with different managements derived from various approaches described in the literature. Where there are divergent or currently unresolved views on the investigation or management of a particular disease, we have attempted to state our own opinion and practice so as to provide some guidance rather than to leave the reader perplexed.
The manual is not designed as a tome containing the minutiae of basic physiology, biochemistry, genetics,
molecular biology, cellular kinetics, and other esoteric and abstruse detail. These subjects are covered extensively in larger works. Only those basic science advances that impinge on clinical practice have been included here.
Each chapter stresses the pathogenesis, pathology, diagnosis, differential diagnosis, investigations, and detailed
therapy of hematologic and oncologic diseases seen in children. I would like to thank Ms Joan Dowdell and Ms Helen Witkowski for their expert typing and for their untiring assistance in the various phases of the development of this book.